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KMID : 0376219770140020385
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Chonnam Medical Journal
1977 Volume.14 No. 2 p.385 ~ p.389
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Effect of Antineoplastic Drugs and Specific Phage on Pseudomonas Infection in Mice
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Abstract
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Attempts to increase the susceptibility of mice to pseudomonas infection by treatment with antineoplastic drugs and to, protect the mice from , Pseudomonas infection with-pseudomonas phage resulted in the following observations.
Methotrexate(160mg/kg), prednisolone(80mg/kg), and cyclophosphamide(300 mg/kg) treatment increased the susceptibility of mice to intraperitoneal pseudomonas infection, the effect being greatest in the methotrexate-treated group.
Intraperitoneal administration of pseudomonas phage protected the mice treated with prednisolone or cyclophosphamide as well as the normal ones. Pseudomonas phage, however, could´nt protect the mice challenged with heavy inoculum of the organism.
Nonencapsulated strain of Pseudomonas aeruginosa appeared to be more virulent to mice than encapsulated one.
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KEYWORD
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